ISOLATE
The scene should be isolated to mitigate consequences. Effective scene management ("Hot-zone" management) is required to control access to and from the incident scene, control movement of contaminated victims, provide safe working methods for responders and contain the release of any substances.
Once the area is isolated, try to identify the material involved in the incident; you can refer to the ERG (Emergency Response Guidebook) to help identify the material and determine the appropriate immediate steps to take.